| خلاصه مقاله | A 37-year-old female with complication of a large mass in her right mandible, which may have originated from the parathyroid gland. According to her CT scan, there was an expansible lesion in her mandible body, measuring 80x55 mm, extended to the lower ramus, resulting in the displacement of her inferior alveolar nerve canal to the superior and medial sides. Two possible diagnoses were considered: intraosseous atypical form of neurofibroma, and ossifying fibroma.
Biopsy results of this mass showed a vascular myxoid spindle cell lesion, and it was recommended to repeat it due to the incompleteness of the biopsy sample. During the blood test on the patient, Ca=9.2, P=2.5, and PTH=629 were detected. A repeat test after an interval of eight days showed Ca=9.8, iPTH= 738, and VitD3=8. Testing results led to a request for parotid scanning by SPECT method using 99mTc-MIBI. Following intravenous injection of 15 mci of the radiotracer, the patient's neck and mandible were scanned in planar and SPECT modes at 15 and 120 min intervals (early and delayed phases).
According to the parathyroid scan, the lower part of the Left thyroid’s lobe showed focally increased uptake, which also retention of the radiotracer in delayed images. The right mandible mass also displayed irregular increased uptake with deformity. According to the scan findings, highly probability of parathyroid adenoma in the left lower lobe, as well as, expansible tumoral involvement in the right mandible with MIBI avid pattern was highly supposed. The probable final diagnosis was hyperparathyroidism jaw tumor syndrome.
Afterward, the patient underwent parathyroidectomy and jaw mass resection. As a result of the pathology report, parathyroid carcinoma was diagnosed. |