چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| مهدی اصغری عظمی | اول |
| مهین آهنگر اسکوئی | دوم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Alzheimer, diagnosis, proteomics, MALDI-TOF MS, peptide profiling |
| خلاصه مقاله | Introduction Alzheimer's disease is growing more prevalent in our aging community. So yet, no effective medication to cure the disease's cause has been established, according to our knowledge. As a result, early detection is required, which will result in the deployment of a medication therapy targeted at reducing or slowing illness progression. Mass spectrometry (MS) especially Matrix-Assisted Laser Desorption Ionization–Time of Flight (MALDI-TOF) MS methods offer a wide range of applications in proteomics and the search for biomarkers of neurodegenerative illnesses, bringing up new diagnostic options. Materials & Methods : For this study, the keywords 'Alzheimer ',' proteomics', ' MALDI-TOF MS', and 'diagnosis' in the databases PubMed, Google Scholar, and Sid between 2017 and 2023 were searched and 12 articles were selected, studied and analyzed. Results: MS spectra analysis allows for the identification of proteins in bodily fluids (such as cerebrospinal fluid or blood). Protein concentration fluctuations have been linked to disease conditions in an organism and can thus be considered biomarkers. Creating techniques for proteome analysis might lead to faster diagnosis and better-suited medications. For example in AD, the proteomic study showed the upregulating of the amyloid precursor protein (APP), which plays a critical role in the pathogenesis of Alzheimer's disease because of its aberrant cleavage by β & γ secretase producing β-amyloid peptide, which collects into neurotoxic amyloid plaques in brain tissues and is effective in the progression of Alzheimer's disease, which MALDI-TOF MS is helpful in the diagnosis of this important biomarker. Conclusion: It is noting that AD is an irreversible neurodegeneration illness in which numerous cellular pathways and biological processes are disrupted. Therefore, the accurate and fast diagnosis of this disease has great importance, and MS-based methods are among these techniques, and other novel effective methods should also be prosessed in the diagnosis of this disease. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| proteomic.pdf | 1402/06/20 | 251543 | دانلود |
| proteomicgovahi.pdf | 1402/06/20 | 178389 | دانلود |
