چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| سیامک شیوا | اول |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Introduction: Gonadotrophin releasing hormone analogues (GnRHas) have been the gold standard therapy for central precocious puberty (CPP) for more than 30 years. These drugs suppress gonadotropin secretion through the desensitization and downregulation of GnRH receptors by exposing them to continuous rather than pulsatile GnRH release, leading to the decrease in gonadal steroid levels to prepubertal levels. GnRH Analogs:In the early 1980s, several different formulations of GnRHas were developed with different durations of action and routes of administration. The 1-month depot formulation of GnRH analogue is the primary formulation used in the treatment of CPP. It provides a steady release of the drug and significantly improves the short-and long-term outcomes in children affected by CPP without adverse effects during and after the treatment. During the past decade there has been a substantial increase in the number of extended-release formulations of GnRHas. Triptorelin: Triptorelin is a synthetic GnRH agonist, first registered in France in 1986. Triptorelin has been widely used in its 3.75 mg formulation for CPP, which is administered every 28 days. A new depot formulation is now available at a dose of 11.25 mg which produces a slow kinetic release over 3 months. Summary: Pharmacodynamic effects of long-acting triptorelin 3-month are similar to those previously reported with the monthly formulation of the same drug. Efficacy of long-acting triptorelin 3-month is comparable to 1-month depot regarding hormonal suppression and inhibition of bone maturation.Long-acting triptorelin 3-month formulation (11.25 mg) may improve compliance and injection monitoring, leading to better short- and long-term outcome of children with CPP. |
| کلمات کلیدی | Triptorelin 3-Month Central Precocious Puberty Gonadotrophin releasing hormone analogues |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Dr.Shiva.pdf | 1402/06/16 | 139726 | دانلود |
| Certificate. Dr.shiva.pdf | 1402/06/16 | 186110 | دانلود |
