| خلاصه مقاله | This meta-analysis was conducted to determine the relationship between neutrophil to lymphocyte ratio (NLR) and febrile seizure
(FS). Our study was registered with the PROSPERO (ID: CRD42021259944). Web of Science, Embase, PubMed, Scopus, and
ProQuest Central were searched, and finally, 17 studies were included. Standardized mean difference (SMD) was reported with
a 95% confidence interval (CI) for the NLR levels. Compared with the febrile control group, the FS patients’ NLR levels were
significantly higher (SMD = 0:49; 95%CI = 0:26 to 0.72, P < 0:001). Furthermore, we conducted a comparison of NLR levels
between febrile controls against simple and complex FS cases separately and found that NLR levels of children with either
simple or complex FS were higher compared with those of febrile controls (SMD = 0:42, 95%CI = 0:14 to 0.69, P = 0:003 and
SMD = 0:90, 95%CI = 0:71 to 1.09, P < 0:001, respectively). Also, in comparison with the NLR levels of the simple FS group,
the complex FS patients’ NLR levels were significantly higher (SMD = 0:59, 95%CI = 0:34 to 0.85, P < 0:001). Our study
indicated that NLR could be recommended as an inexpensive diagnostic biomarker for FS. In addition, it can be useful when
distinguishing between simple FS and complex FS. |