| خلاصه مقاله | Tissue engineering, a form of regenerative medicine, uses a combination of cells, engineering methods, materials, and appropriate biochemical and physicochemical agents to construct appropriate structures for the regeneration, maintenance, improvement, or replacement of various types of biological tissues. In this path, tissue engineering has used new technologies and created new methods for engineering tissue structures that can be used for different purposes and in various areas of regenerative medicine. For the past 25 years, the advancement of tissue engineering has been mostly reliant on technological progress. The next generation of tissue engineers will need to adopt cutting-edge technologyto advance. In this regard, significantadvancementshavebeen made in 3D bioprinting, organ-on-a-chip, spatially-resolved-omics, gene editing, cell trans-differentiation and direct reprogramming, induced pluripotent stem cell (iPSCs)technology, decellularization and recellularization, and artificial intelligence. Also, we may see a future where automated culture systems are utilized to produce customized tissue constructions using computational predictions from machine learning algorithms. These technologies and their correct understanding will have a significant impact on the success of tissue engineering in various fields of medicine and transforming it into regenerative medicine. |