چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| مریم قهرمانی نسب | اول |
| عزیزه رحمانی دل بخشایش | دوم |
| نعیمه اکبری قرالری | سوم |
| احمد مهدی پور | چهارم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | It is interesting to investigate the mechanism underlying the enhancement of wound healing in a mesenchymal stem cell-conditioned medium (MSC-CM), which is enhanced by hypoxia. Hypoxia promotes the proliferation of AF-MSCs and protects their inherent characteristics (expressed surface markers and differentiation potentials). It is noteworthy that amniotic fluid-derived mesenchymal stem cells (AF-MSCs) secrete more paracrine factors, such as VEGF and TGF-β1, in the hypoxic conditioned medium (AF-MSC-hypoCM) than AF-MSC-norCM. In addition, AF-MSC-hypoCM improves wound healing in a skin injury model and the proliferation and migration of human dermal fibroblasts in vitro compared to AF-MSC-norCM. Wang et al. conducted a study in which AF-MSC-hypoCM-enriched fibroblast migration was inhibited by SB505124 and LY294002, TGF-β/SMAD2 and PI3K/AKT inhibitors, and their findings demonstrated that wound healing is improved by hypoCM-enriched media with AF- MSCs. In conclusion, AF-MSC-hypoCM promotes the production of hypoxia-induced paracrine factors by activating the TGF-β/SMAD2 and PI3K/AKT pathways, thereby affecting wound healing. |
| کلمات کلیدی | Wound Healing, Hypoxia, Conditioned Medium |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Certification.pdf | 1402/05/14 | 162751 | دانلود |
| Poster.pdf | 1402/05/14 | 1119572 | دانلود |
