چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| مریم قهرمانی نسب | اول |
| احمد مهدی پور | دوم |
| نعیمه اکبری قرالری | سوم |
| عزیزه رحمانی دل بخشایش | چهارم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Key words: Exosome, wound-healing, macrophage, umbilical cord |
| خلاصه مقاله | Wound-healing is a complex and important biological process cooperating physicochemical and cellular factors. There are many studies on wound-healing and an important part of these studies is related to the effect of exosomes on wound-healing. Exosomes are originated from endosomal vesicles of parental cells into the extracellular environment, containing various lipids, proteins, mRNAs, LncRNAs, miRNAs, CircRNA to regulate the activity of receiver cells and have main role in tissue regeneration as they can effect on tissue responses to injury. Now a day, cell-therapy is used in medicine with a lot of limitations, and exosomes are popular to overcome the limitations. Exosome-therapy is probably effective candidate due to ease of restoration and transportation. Existing literature shoes the potency of MSC-EVs (MSC-Derived Exosomes) on accelerating wound-healing at different phases even improving scar. Exosomes derived from BM-MSCs that carry miR-223 can enhance wound-healing in mice and induce M2 macrophage polarization by decreasing TNF-α and increasing IL-10 in the inflammatory phase. Exosomes derived from Human umbilical cord (UC)-MSCs that carry let-7b can accelerate diabetic cutaneous wound-healing in rats and induce M2 macrophage polarization also inhibit TLR4 signaling pathway due to decrease in iNOS, TLR4, p-p65 and increase in ARG1 and p-AKT in the inflammatory phase. Furthermore, UC-MSCs-exosomes containing miR-181c can decrease TNF-α, IL-1β and increase IL-10 therefore reducing burn-induced inflammation in rats, reducing neutrophil and macrophage infiltration, and inhibit TLR4 signaling pathway. Now a day, exosome therapy is a novel therapeutic model as a replacement for cell-therapy by decreasing side effects of current methods. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Poster.pdf | 1402/05/13 | 566499 | دانلود |
| Certification.pdf | 1402/05/13 | 281636 | دانلود |
