| خلاصه مقاله | Electrospinning is considered one of the most attractive techniques in the development of advanced bioactive dressings due to its easy process, flexibility, ability to imitate the native structure of ECM, facilitation of the wound healing process, and ability to be performed with different biological materials. As an emerging technology, electrospinning provides a unique opportunity to engineer effective wound dressings and care products, and hence more effectively manage wound healing. Recently, for the treatment of chronic and acute wounds, there has been a great focus on the development of suitable fibrous bioactive dressing materials using this approach. In this regard, various composite fibers are made from different natural and synthetic polymers for effective wound treatment and management. Also, various medicinal and biological agents are used in the structure of fibrous dressings to control pain, prevent infection, or induce tissue repair and regeneration so that the wound healing process goes well without possible complications. Considering the importance of this issue, in this review, we focus on the latest developments in the fabrication and use of bioactive electrospun scaffolds for wound healing. In addition, special attention is paid here to multifunctional and 'smart' fibrous scaffolds developed by electrospinning-based approaches. Finally, various types of advanced fibrous scaffolds such as core-shell fibers, three-dimensional multi-layered scaffolds, and surface-modified fibrous scaffolds by multiple modifications are also mentioned. |