| خلاصه مقاله | Background and Aim: The outbreak of novel severe acute respiratory syndrome coronavirus 2
(SARS- CoV2) in 2019, drew significant attention and effort as a global health concern. In spite
of partial control of pandemic, it is still remained as one of the hot topics. The symptoms of
COVID-19 varied widely from a mild respiratory involvement to multi organ failure or death.
Neurological manifestations were reported as challenging features in COVID-19 patients. Four
limbs weakness was one of the rare but significant complications following COVID-19 which we
reported in our case series and looked for the underlying context using electrodiagnostic studies.
Methods: We presented Six patients with the diagnosis of COVID-19, who developed
concomitant quadriparesia. All of the patients were hospitalized in Imam Reza Hospital, Tabriz
and were referred to Physical Medicine and Rehabilitation center for electrodiagnostic studies.
After history taking and clinical examination the patients underwent EMG/NCS studies.
Results: The interpretation of findings revealed 3 axonal variants of Guillain–Barré syndrome
(GBS), including; 2 cases AMAN (acute motor axonal neuropathy), 1 case AMSAN (acute motor
and sensory axonal neuropathy), 3 myopathies, including one combination of CIN/CIM (critical
illness neuropathy/critical illness myopathy), one CIM and one acute polymyositis in these cases.
Conclusion: Electrodiagnostic studies could play an important role in the diagnosis of
neuromuscular disorders of coronavirus to facilitate correct treatment planning in COVID-19
patients. Since GBS and inflammatory myopathies have an autoimmune basis, the
immunotherapies such as IVIG, steroids, plasma exchange and other novel treatments as hemoperfusion can provide promising recovery in respiratory function as well as neuromuscular
activity among COVID-19 patients who have musculature paralysis concomitantly. However, all
of these options are challenging and further clinical trials is needed. |