چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| لیلا حسینی | اول |
| هانیه صالحی پورمهر | دوم |
| نسرین ابوالحسن پور | سوم |
| فریبا پاشازاده | چهارم |
| ویدا مافی کندی | پنجم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Data from preclinical studies propose nicotinamide adenine dinucleotide (NAD+) as a neuroprotective and bioenergetics stimulant agent to treat Alzheimer’s disease (AD); however, there seems to be inconsistency between behavioral and molecular outcomes. We performed this systematic review to provide a better understanding of the efects of NAD+ in rodent AD models and to summarize the literature. Studies were identifed by searching PubMed, EMBASE, Scopus, Google Scholar, and the reference lists of relevant review articles published through December 2020. The search strategy was restricted to articles about NAD+, its derivatives, and their association with cognitive function in AD rodent models. The initial search yielded 320 articles, of which 11 publications were included in our systematic review. Based on the primary outcomes, it was revealed that NAD+ improves learning and memory. The secondary endpoints also showed neuroprotective efects of NAD+ on diferent AD models. The proposed neuroprotective mechanisms included, but were not limited to, the attenuation of the oxidative stress, infammation, and apoptosis, while enhancing the mitochondrial function. The current systematic review summarizes the preclinical studies on NAD+ precursors and provides evidence favoring the pro-cognitive efects of such components in rodent models of AD. |
| کلمات کلیدی | Alzheimer’s disease · Cognition · Neuroprotection · Nicotinamide · Rodent |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Leila Hosseini.Certificate.pdf | 1402/04/07 | 248639 | دانلود |
| Leila Hosseini.pdf | 1402/04/07 | 332984 | دانلود |
| Abstract.pdf | 1402/04/07 | 107721 | دانلود |
