چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | توحید مرتضی زاده |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | دانشکده پزشکی |
| کد مقاله | 81724 |
| عنوان فارسی مقاله | Trastuzumab Polyethylene Glycol Modified Gold Nanoparticle As Potential Targeted Contrast Agent in Molecular CTIimaging of Cancer Cells . |
| عنوان لاتین مقاله | Trastuzumab Polyethylene Glycol Modified Gold Nanoparticle As Potential Targeted Contrast Agent in Molecular CTIimaging of Cancer Cells |
| نوع ارائه | سخنرانی |
| عنوان کنگره / همایش | کنگره رادیولوژی ایران |
| نوع کنگره / همایش | ملی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | |
| سال انتشار/ ارائه شمسی | 1402 |
| سال انتشار/ارائه میلادی | 2023 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1402/02/19 الی 1402/02/22 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://www.isr.org.ir/Congress/2023 |
| آدرس علمی (Affiliation) نویسنده متقاضی | Department of Medical Physics, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. |
| نویسنده | نفر چندم مقاله |
|---|---|
| توحید مرتضی زاده | اول |
| یاسین ایامی | دوم |
| معصومه دستگیر | سوم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | The development of different effective multifunctional nano-probes for efficient targeted molecular imaging of tumors has presents a great challenge in medicine. Herein, we reported the in-vitro targeting of Trastuzumab (TZ) multifunctional Fe3O4 coated gold nanoparticles (Fe3O4@Au NPs) through Polyethylene glycol (PEG) linking for targeted tumor molecular computed tomography (CT) imaging method. The prepared multifunctional PEG-TZ conjugated Fe3O4@Au NPs (TZ-PEG-Fe3O4@Au NPs) were fully characterized via different procedures. MTT, hematoxylin and eosin (H&E) assays were used to evaluate the cytocompatibility of the synthesized NPs. The findings showed that the synthesized TZ-PEG-Fe3O4@Au NPs, which have a size of less than 100 nm and are non-cytoxic at a specific concentration range, exhibit better X-ray attenuation intensity than iodine-based contrast agents at the same concentration. When compared to iodine at a concentration of 2000 g/ml, TZ-PEG-Fe3O4@Au NPs permit around 1.6 times more contrast per unit mass at 80 kVp. The created targeted NPs can be employed as a contrast agent for in vitro targeted CT imaging of cancer cells expressing the HER-2 receptor. At 80 kVp, the targeted cells' CT values were higher than those of untargeted cells. These results clearly show that the TZ-PEG-Fe3O4@Au NPs may be effectively used as a contrast agent in molecular CT imaging. |
| کلمات کلیدی | Contrast Agent; Molecular CT imaging; Trastuzumab; Gold nanoparticles; Cancer. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| First Page.pdf | 1402/03/17 | 1292427 | دانلود |
| Abstract Book.pdf | 1402/03/17 | 3383151 | دانلود |
| TZ CT.pdf | 1402/03/17 | 263018 | دانلود |
