| خلاصه مقاله | Background: Since the outbreak of COVID-19, various treatments have been
frequently reported for patients infected with this virus, especially in transplant
patients/recipients.
Objective: Investigating of kidney transplant patients under immunosuppressive
therapy infected with COVID-19 can pave the way to understanding, handling, and
treatment of COVID-19.
Methods: We had a brief review of the literature on immunosuppressive therapy in
kidney transplants infected with COVID-19. This was based on the PubMed
Database with keywords “kidney, transplant, COVID-19, and immunosuppress”
after hospitalization of kidney transplantation infected with COVID-19. He had
already been recorded in the Organ Transplant Registry (ID≠ 64510) of Tabriz
University of Medical Sciences /Iran.Results: We reported the clinical course of a 45-year-old man with a history of
kidney transplantation and immunotherapy who was infected with COVID-19 with
respiratory infections and positive RT-PCR (Real-time polymerase chain reaction).
He was treated with hydroxychloroquine, Kaletra, CellCept, and prednisolone for 5
days, and finally discharged from the hospital. In addition, reviewing of 47 papers
with 851 samples showed that
immunosuppressant medications alone could be a therapeutic choice in kidney
transplants infected with COVID-19 with careful management.
Conclusion: Patients with organ transplantation infected with COVID-19 may
show different clinical signs, clinical course, and prognosis due to underlying
diseases and the use of immunosuppressant medications. It might be best to
continue taking the immunosuppressant medications but modify them based on the
patients' conditions such as clinical symptoms, laboratory results, paraclinical
examinations. |