چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | الهام احمدیان |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | مرکز تحقیقات کلیه |
| کد مقاله | 81647 |
| عنوان فارسی مقاله | The radiosensitizing effect of herbal active component, betanin, in prostat cancer |
| عنوان لاتین مقاله | The radiosensitizing effect of herbal active component, betanin, in prostat cancer |
| نوع ارائه | سخنرانی |
| عنوان کنگره / همایش | Drug Research and Development (DRD) 2023 |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Turkey |
| شهر محل برگزاری کنگره/ همایش | izmir |
| سال انتشار/ ارائه شمسی | 1402 |
| سال انتشار/ارائه میلادی | 2023 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1402/02/14 الی 1402/02/16 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://www.drd2023.org/ |
| آدرس علمی (Affiliation) نویسنده متقاضی | Kidney Research center, Tabriz University of Medical Sciences, Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| الهام احمدیان | اول |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Prostate cancer is among the most prevalent cancers among men with an increasing incididence rate. Radiation therapy (RT) is a treatment modality for the management of prostate following surgery; however, it has different side effects on neighburing healthy tissues/cell.morover, radioresistance is an incresing phenomanoa in the recent years. Therefore, there is an urgent need for the introduction of a safe and effective radiosensitizing agent. Our study, evaluated the effects of betanin in combination with RT as a possible radiosensitizing agent in PC-3 cell line. MTT assay was used to assess the growth inhibitory effect of betanin. The possible synergistic effect was evaluated with CompuSyn software upon Trypan blue exclusion assay. The protein expression of P21 was determined using western blotting. Apoptosis-related gene expression was evaluated via Real time PCR. treatment of PC-3 cells with betanin combined with RT resulted in synergistic anticancer effects with an optimum combination index of 0.61. the results indicated that betanin synergistically triggered RT-induced apoptosis and cell cycle arresst through modulating gene and protein expression in comaprison with monotherapies. These fndings highlight the potential effect of betanin as a radiosensitizer, indicating the synergistic anti-cancer efect of betanin and RT in prostate cancer. |
| کلمات کلیدی | betanin, radio sensitivity, radio resistance, prostate cancer |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| program.pdf | 1402/03/02 | 428605 | دانلود |
| ELHAM AHMADIAN.pdf | 1402/03/02 | 2067079 | دانلود |
| thumbnail.jpg | 1402/03/02 | 95046 | دانلود |
| betanin.docx | 1402/04/05 | 12438 | دانلود |
