چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | سید امین سیدرضایی |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | دانشکده پیراپزشکی |
| کد مقاله | 81619 |
| عنوان فارسی مقاله | Using Neurofilaments in Multiple Sclerosis Diagnosis and Monitoring |
| عنوان لاتین مقاله | Using Neurofilaments in Multiple Sclerosis Diagnosis and Monitoring |
| نوع ارائه | پوستر |
| عنوان کنگره / همایش | The 14th International & 20th National Congress on Quality Improvement in Clinical Laboratories |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | Tehran |
| سال انتشار/ ارائه شمسی | 1402 |
| سال انتشار/ارائه میلادی | 2023 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1402/02/26 الی 1402/02/29 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://iqctehran.ir |
| آدرس علمی (Affiliation) نویسنده متقاضی | DepartmentofLaboratorySciences,FacultyofParamedicine,TabrizUniversityofMedicalSciences,Tabriz,Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| سید امین سیدرضایی | اول |
| محمد اصغرزاده | دوم |
| وحید اصغرزاده | سوم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Keywords: multiple sclerosis, MS, neurofilaments, NF |
| خلاصه مقاله | Background: Multiple sclerosis (MS) is a chronic, inflammatory disease of the central nervous system (CNS). This disease causes demyelination and neurodegeneration in the CNS, which is followed by symptoms such as mobility problems, vision problems and numbness. Early diagnosis of MS plays a key role in preventing the progression of the disease and reducing its symptoms. Using different biomarkers, such as neurofilaments (NF), is a useful method to help early identification of MS patients. Neurofilaments are neuronal cytoskeletal proteins and are composed of a light chain (NFL), an intermediate chain (NFM), and a heavy chain (NFH). Neurofilaments are expressed only in neurons and are released into the cerebrospinal fluid (CSF) and blood after neuroaxonal damage. Methods: We reviewed about 200 articles about neurofilaments, multiple sclerosis and relationship between them from January 1, 2018, to November 30, 2022, and finally used information in 10 of them to write this article. Results: During this disease, the patient experiences neuroaxonal damage, which results in the release of neurofilaments into the CSF and blood stream. Therefore, compared to healthy people, MS patients have higher levels of NFL in their CSF and blood circulation. After the effective treatment of this disease, the increased levels of NFL will decrease significantly. Conclusion: Therefore, measuring the levels of NFL in serum and CSF can be a suitable method to help in the early diagnosis of this disease. NFL measurement can also be used to check the treatment process and monitor the therapy response. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| final nf and ms.pdf | 1402/02/29 | 4034264 | دانلود |
| IMG_20230516_155321.pdf | 1402/02/30 | 23880698 | دانلود |
