چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| زهره صناعت | اول |
| حسین آذری بستان آباد | دوم |
| مرتضی رئیسی | سوم |
| اشرف فخرجو | چهارم |
| پروین سربخش | پنجم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Breast cancer, outcome, TILs, DFS, OS |
| خلاصه مقاله | Goals: Breast cancer is the most common cancer, and the second most common cause of death in women. Tumor-infiltrating lymphocytes (TILs) play an essential role in mediating response to chemotherapy and improving clinical outcomes which opens the possibility for new treatment options through modulation of immune response. TILs have been shown to provide prognostic and potentially predictive value, particularly in triple-negative and HER2 type breast cancer but the role and the effect of TILs on prognosis in luminal breast cancer is less clear. We evaluated relationship between TILs and clinical outcome were defined as disease-free survival (DFS) and overall survival (OS) in all sub types of breast cancer. Methods: 228 patients with non-metastatic breast between (2009– 2019) were enrolled. Paraffin blocks (biopsies) that confirmed by pathologist were included and assessed by H&E staining for number of TILs. The association between clinicopathologic parameters, prognosis(DFS, OS) and TILs were evaluated. Results: The mean ± SD age of the patients was 48.42 ± 9.62 years (range: 27–77 years). About 90.7% of cases were younger than 65 years old. 32 (14%) of the patients were in stage I, 29 (56.6%) were in stage II and 67 (29.4%) were in stage III of breast cancer.134 patients (58.8%) had TILs (TILs positive), And 94 patients (41.2%) did not have lymphocyte infiltration in breast cancer tissue (TILs negative).100 patients (43.9%) had TILs ≤ 30%, 12 patients (5.3%) had TILs, 31–49% and 22 patients (9.6%) had TILs ≥50%. The mean of TILs were 23.29% ± 15.77%. Relationship between TILs and age, stage were not statistically significant, but Relationship between TILs and subtype of breast cancer was statistically significant (P-value <0.001). Disease Free Survival two, five and ten years were 99.6%, 94%, and 80.1%, respectively. Overall Survival two, five and ten years were 99.6%, 97.6%, and 82.9%, respectively. The Univariate Cox regression and adjusting for confounding variables with multivariate Cox regression analysis showed that DFS and OS were not association with TILs. Prognostic Factor Patient (n) 228 <=30% TILs + 31–49% >=50% TILs– n (%) P-Value <=35years 11 62.5% 12.5% 25% 3 (27%) Age 36–65years 207 74.2% 9.2% 16.7% 87 (42%) 0.613 >65years 10 100% 0% 0% 4 (40%) Stage I 32 83.3% 8.3% 8.3% 4 (40%) II 129 79.4% 4.4% 16.2% 61 (47%) 0.272 III 67 66.7% 14.8% 18.5% 13 (19.4%) Luminal A 174 84.4% 4.2% 11.5% 78 (44.8%) 0.602 Luminal B 26 40.9% 27.3% 31.8% 4 (15.4%) <0.001 HER2+ 11 28.6% 29.6% 42.9% 4 (36.4%) <0.001 TNBC 17 89.9% 0.0% 11.1% 8 (47%) 0.855 Correlation of clinical and pathological findings with TILs Conclusion(s): The results from this study suggest that TILs is associated with subtype of breast cancer. From the survival analysis, there were no statistical difference in overall survival and disease free survival with TILs. Further studies with larger sample sizes are recommended for further investigation. |
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| BCC 2023 CME Certificate.pdf | 1402/02/04 | 156727 | دانلود |
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