| خلاصه مقاله | Epilepsy management in elderly
Saeid Charsouei ,MD , Associate Professor of Neurology , Fellowship in Epilepsy ,
Tabriz University of Medical sciences
• In the most patients ,a clear diagnosis of epilepsy can be not challengeable .
However, making a clear diagnosis can be a challenge in some elderly patients , because the clinical manifestations of seizures , the differential diagnosis ( stroke,metabolic disorders,syncope or nonepileptic confusional states, REM behavior disorders,Dementia,Parkinson disease, transient global amnesia and migraine) and etiology of epilepsy can be different in the elderly compared with younger individuals.Thus the true prevalence of epilepsy in older people remains difficult to determine with certainty too .
• Seizures in older people are sometimes atypical. Auras are less commonly reported. Automatisms can be less frequent, and postictal confusion can be more prolonged, lasting up to days . Focal seizures in the elderly may be associated more frequently with Todd’s paresis, and postictal confusion may last longer than 24 hours and be complicated by prolonged aphasia. Antiepileptic drugs (AED) monotherapy and the use of newer AEDs such as gabapentin (GBP), LTG, or levetiracetam (LEV) are preferable in the elderly . Adverse effects of AED treatment can be minimized by slow dose escalation up to average daily maintenance doses . The management of status epilepticus in elderly patients differ only slightly from younger patients . Status epilepticus has a higher mortality in the elderly.
• Epilepsy surgery appears to be increasingly considered for some older adults with focal epilepsy, although there are problems. Seizure-free rates can be comparable to younger age groups , but the rate of surgery-related complications may be higher in the elderly compared to younger patients. |