چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| مریم حسین پور سرمدی | اول |
| فرشاد جوادزاده | دوم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Background: Lichen planus, is considered as a premalignant condition with an unknown etiology. The present study aimed to determine the IgG serum levels in different oral lichenoid lesions before and after treatment with topical corticosteroids. Materials and Methods: Two groups of 23 individuals, including oral ulcerative lichenoid lesions patients (OULP)and healthy ones were evaluated. Biopsy was carried out while VAS (Visual Analog Scale) was used for an evaluation of symptoms. By applying local corticosteroids, IgG serum levels were determined before, three weeks after, and at the end of the study (9 weeks) with ELISA and turbidimetry methods respectively. Results: While IgG serum level was significantly higher before the intervention (p=0.01), it was decreased significantly in the case group after treatment (p=0.02). In addition, pain intensity was reduced significantly in the case group(p=0.05). Conclusion: the level of serum IgG in patients with OULP is higher than in the control group, IgG serum level and pain severity were effectively decreased among the treated with topical corticosteroids. If these results are confirmed by further studies, it can be used to identify the etiology of lichen planus, which is a premalignant lesion, and with further research on other treatments that can reduce this biomarker, it can also be used to treat lichen planus. |
| کلمات کلیدی | IgG · Topical steroids · oral lichenoid lesions · visual analog scale |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| icb-1135.pdf | 1401/12/22 | 1444080 | دانلود |
| icb-1135___12602.docx | 1401/12/22 | 22739 | دانلود |
| icb-1135___Pr47B.jpg | 1401/12/22 | 290451 | دانلود |
