چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | کتایون کاتبی |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | دانشکده دندانپزشکی |
| کد مقاله | 81115 |
| عنوان فارسی مقاله | Comparison of serum and salivary folate levels in patients with oral squamous cell carcinoma |
| عنوان لاتین مقاله | Comparison of serum and salivary folate levels in patients with oral squamous cell carcinoma |
| نوع ارائه | پوستر |
| عنوان کنگره / همایش | First International Congress of Biomarkers |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | ارومیه |
| سال انتشار/ ارائه شمسی | 1401 |
| سال انتشار/ارائه میلادی | 2023 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1401/12/03 الی 1401/12/05 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://icb.umsu.ac.ir/Home/Index |
| آدرس علمی (Affiliation) نویسنده متقاضی | Faculty of dentistry, Tabriz university of medical sciences, Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| آیلا بهرامیان | دوم |
| کتایون کاتبی | اول |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Biomarkers, Folic acid, Saliva, Squamous Cell Carcinoma of Head and Neck |
| خلاصه مقاله | Background: Oral cancer is the sixth most common cancer in males and the fifteenth in females. Folate is essential for maintaining normal function of nucleotide synthesis and DNA methylation. Disruption of folate metabolism can lead to abnormal cell activity and proliferation. The aim of this study was to compare the serum and salivary levels of folate in patients with oral squamous cell carcinoma (SCC) with healthy subjects. Materials and Methods: In this cross-sectioned study, 30 patients with oral SCC referred to oral and maxillofacial department and 30 healthy individuals were studied. Two cc saliva and 5cc venous blood were taken from participants and were evaluated with Human Folate ELISIA Kit. Independent T test and Pearson correlation coefficient was used and statistical analysis was done using SPSS 17. The result was considered to be significant if the P-value was less than 0.05. Results: Serum folate levels in patients with oral squamous cell carcinoma (8.18 ± 4.37 ng/mL) were significantly lower than healthy subjects (10.61±5.79 ng/mL) (P=0.005). It was also found that folate levels in saliva were significantly lower in patients with squamous cell carcinoma (1.13 ± 1.32 ng/mL) than healthy subjects (2.84 ± 4.40 ng mL) (p= 0.029). Serum folate levels in patients with oral SCC (rp=0/135, P = 0/006) and healthy controls (rp=0/133, P = 0/003) were correlated with salivary folate levels. Conclusion: Since the levels of serum and salivary folate in patients with oral squamous cell carcinoma were significantly lower than that of healthy individuals, low folate levels are likely to be associated with oral SCC. Also, it might be possible to use salivary samples instead of a serum to check the folate level as a non-invasive method. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| poster folate.jpg | 1401/12/14 | 1371701 | دانلود |
| icb-1137___73764.docx | 1401/12/14 | 15579 | دانلود |
| icb-1137.pdf | 1401/12/14 | 1439815 | دانلود |
