چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | داود خضرلو |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | دانشکده پیراپزشکی |
| کد مقاله | 81093 |
| عنوان فارسی مقاله | آتروفی سابفیلدهای هیپوکامپ به عنوان نشانگر زیستی در بیماران مبتلا به بیماری آلزایمر و اختلال شناختی خفیف (MCI) |
| عنوان لاتین مقاله | Atrophy of Hippocampal Subfields as a Biomarker in Alzheimer's Disease and Mild Cognitive Impairment(MCI) Patients |
| نوع ارائه | پوستر |
| عنوان کنگره / همایش | 1st International Congress of Biomarkers |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | ارومیه |
| سال انتشار/ ارائه شمسی | 1401 |
| سال انتشار/ارائه میلادی | 2023 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1401/12/03 الی 1401/12/05 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://icb.umsu.ac.ir/Home/Index |
| آدرس علمی (Affiliation) نویسنده متقاضی | Department of Radiology, Faculty of Allied Medical Sciences, Tabriz University of Medical Science, Tabriz, Iran. (khezerlood@tbzmed.ac.ir ) ORCID ID: 0000-0003-2337-4067 |
| نویسنده | نفر چندم مقاله |
|---|---|
| داود خضرلو | اول |
| امیررضا جهانشاهی | دوم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Keywords: Alzheimer's disease(AD), mild cognitive impairment(MCI), Hippocampal subfields, MRI, Brain atrophy |
| خلاصه مقاله | Background: Atrophy in hippocampal subfields analysis based on MRI is widely used as a powerful biomarker for the diagnosis and management of neurocognitive diseases. However, there is still no clear consensus on the atrophy pattern in Alzheimer's disease (AD) and mild cognitive impairment (MCI). In this cross-sectional study, hippocampal subfield atrophy in AD and MCI patients is extracted and compared with the normal group (NC). in addition, the symmetry of atrophy in the subfields (left and right) is also assessed. Materials and Methods: MRI images used in this study were selected from Alzheimer's database (ADNI). The images of 20 AD, 20 MCI patients; and 20 Normal control (NC) in the age range of 60-65 years were selected and downloaded. The volume of subfields was extracted automatically using Freesurfer version 7.1.0 software; and then normalized to the total intracranial volume. Finally, asymmetry of subfields volumes was also assessed. Analysis of covariance was used to compare the volume of subfields between the three groups (age and gender as covariates). Results: The results showed that the atrophy in the total hippocampus and its subfields in AD was significantly higher than in the NC, as well as in MCI groups. In terms of asymmetry, it was observed that there is a significant difference in the atrophy of the total hippocampus, hippocampal body, fimbria, the CA3 and GC-ML-DG between the AD and NC group as well as MCI group. Conclusion: Atrophy of hippocampal subfields are useful biomarker in neurocognitive diseases. In this study, it was seen that the atrophy of all subfields and its asymmetry can be used for distinguishing Alzheimer's from MCI. It was seen that the pattern of atrophy in the left hippocampal subfields is more than in the right. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| icb-1085-Biomarkers Urmia.pdf | 1401/12/13 | 1444154 | دانلود |
| Biomarker.pdf | 1401/12/13 | 152141 | دانلود |
