چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| سید امین سیدرضایی | اول |
| محمد اصغرزاده | دوم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Background: Multiple sclerosis (MS) is a chronic and inflammatory disease of the central nervous system (CNS) that is common in people between the ages of 20 and 40. This disease has increased significantly in recent decades in different geographical areas. In order to control and reduce the disease prevalence, early identification of at-risk people and patients in the early stages of the disease is important. Melatonin is one of the biomarkers that can be used for early diagnosis of the disease. Melatonin is a hormone that is released from the pineal gland in response to darkness, and it has several functions like regulating the formation and function of immune cells and anti-inflammatory actions on nerve cells. Materials and Methods: We reviewed 200 articles about multiple sclerosis, melatonin, and the relationship between them from January 1, 2016, to July 31, 2022, and finally used information in 10 of them to write this article. Results: depending on the stage of inflammation, this hormone can have both pre-inflammatory and anti-inflammatory properties. Elevated levels of this hormone cause the production of anti-inflammatory cytokines such as interleukin 4 (IL-4) and IL-10, in contrast, reduces inflammatory cytokines such as tumor necrosis factor alpha (TNF-α). Therefore, low levels of melatonin have been linked to neurological problems such as MS. Conclusion: Therefore, measuring melatonin can be helpful in early diagnosis and control of this disease, especially in less advantaged cities and countries. |
| کلمات کلیدی | multiple sclerosis, melatonin, MS |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| icb-1146.pdf | 1401/12/11 | 1439044 | دانلود |
| final mel and ms.jpg | 1401/12/11 | 1983431 | دانلود |
