چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | وحدت پورطهماسبی |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | بیماری های عفونی و گرمسیری |
| کد مقاله | 80959 |
| عنوان فارسی مقاله | Gut microbiota in Ulcerative Colitis and Crohn's Diseases: A Next Generation Based Study |
| عنوان لاتین مقاله | Gut microbiota in Ulcerative Colitis and Crohn's Diseases: A Next Generation Based Study |
| نوع ارائه | پوستر |
| عنوان کنگره / همایش | چهاردهمین کنگره بین المللی آزمایشگاه و بالین |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | تهران |
| سال انتشار/ ارائه شمسی | 1401 |
| سال انتشار/ارائه میلادی | 2023 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1401/11/13 الی 1401/11/15 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://isacl2023.congressapp.ir/post_view.php?id=118 |
| آدرس علمی (Affiliation) نویسنده متقاضی | Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| وحدت پورطهماسبی | اول |
| مسعود شیرمحمدی | چهارم |
| مهین آهنگر اسکوئی | پنجم |
| بهروز نقیلی حکم آبادی | ششم |
| نادر محمدزاده | هفتم |
| آرزو آزادی | هشتم |
| محمد آقازاده | نهم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Background: The microbial population varies at different stages of the disease in Inflammatory bowel disease (IBD) patients and may be associated with the severity of disease and therapy resistance in these patients. The association between IBD is not very well described but gut microbiota composition is mentioned as a risk factor. The present study aimed to characterize the differences of dominant gut microbiota among patients with IBD as compared to control groups. Materials and Methods: Here we characterized the normal human and IBD enteric microbiome by next generation sequencing (NGS) of the 16S rRNA amplification from fecal samples obtained from ulcerative colitis (UC) (n= 20) and Crohn’s disease (CD) (n= 20) patients and controls (n= 0) (Samples collected from Tehran and Tabriz). All subjects are required to have been diagnosed with IBD (several stages) confirmed using standard clinical, endoscopic, and histological criteria. Bacterial microbiota determined by sequencing of the V4 region of the 16S rRNA gene (using Illumina MiSeq, 150-300b Paired-End, 30 Mb). Results: In terms of body mass index (BMI), cholesterol, triglyceride and fasting blood sugar, no significant association were found IBD patients (UC and CD) and healthy controls. The NGS results of IBD patients mainly representatives of several phyla including Proteobacteria, Bacteroidetes, and Firmicutes. Bacteroidetes and Firmicutes phyla were significantly high in IBD patients comparing to healthy subjects. The taxonomic richness and diversity of some viruses in IBD patients are more probable and these microorganisms can be used as biomarkers for disease diagnosis and management. Conclusion: This study performed gut microbiota IBD patients. This investigation indicated that IBD (UC and CD) patients have a different gut composition in comparison to healthy control, which could be associated with disease development. |
| کلمات کلیدی | Inflammatory bowel disease, Microbiome, Ulcerative colitis, Crohn’s disease |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Poster presentation.JPG | 1401/11/23 | 1223382 | دانلود |
| Poster presentation Abstract.pdf | 1401/11/29 | 759889 | دانلود |
