چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | اعظم صفری |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | بیماری های گوارش و کبد |
| کد مقاله | 80863 |
| عنوان فارسی مقاله | Impacts of targeted nanostructures on cellular oxidative stress genes expression in colorectal cancer |
| عنوان لاتین مقاله | Impacts of targeted nanostructures on cellular oxidative stress genes expression in colorectal cancer |
| نوع ارائه | پوسترو سخنرانی |
| عنوان کنگره / همایش | بیست و دومین کنگره بیماریهای گوارش و کبد ایران |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | تهران |
| سال انتشار/ ارائه شمسی | 1401 |
| سال انتشار/ارائه میلادی | 2022 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1401/10/06 الی 1401/10/09 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://iaghcongress.org/fa/CongressItem/C-22-0110/ |
| آدرس علمی (Affiliation) نویسنده متقاضی | Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| مصطفی اکبرزاده خیاوی | اول |
| اعظم صفری | دوم |
| حامد فرضی خواجه | سوم |
| سید کاظم میری نژاد | چهارم |
| محمد حسین صومی | پنجم |
| ساینا ترابی | ششم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | مقدمه Oxidative stress, including reactive oxygen species (ROS), has been known main cause of malignant disorders such as colorectal cancer (CRC). The nuclear factor erythroid 2-related factor 2 (Nrf2)/Kelch-like ECH-related protein 1 (KEAP1) pathway is well known to protect cells from oxidative stress and inflammation. The current study introduced an effective nanomedicine composed of PEGylated super magnetic nanoparticles (SPIONs -PEG) conjugated with Cetuximab (Cet) that can induce ROSs mediating apoptosis pathways for CRC treatment. روش کار The SPIONs are synthesized, stabilized by polyethylene glycol (PEG), functionalized, and covalently conjugated with Cet. The physicochemical properties of engineered nanomedicine (SPIONs -PEG-Cet) were characterized by UV-vis spectrum. Then, the impact of SPIONs -PEG-Cet on cell viability, ROS production, and oxidative stress gene expression (Kaep1- Nerf2) were evaluated in the CRC cell line. نتایج The engineered nanomedicine effectively induced apoptosis in SW-480 cells and significantly reduced cancer cell viability. In addition, the maximum production of ROS was obtained after the treatment of cells with an IC50 dose of SPIONs-PEG-Cet. Based on real-time PCR data, in the treated SW-480 cells with the SPIONs -PEG-Cet, the expression level of Keap1 was significantly increased, while the expression of Nerf 2, were found to be significantly decreased as compared to the untreated control cells. نتیجه گیری In the current study, we introduced a nanoformulation of Cet with a high apoptosis effect on CRC cells compared to the free Cet. |
| کلمات کلیدی | Oxidative stress, Nanostructures, Colorectal cancer, Cetuximab |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 3.pdf | 1401/11/12 | 459214 | دانلود |
| certificate (1).pdf | 1401/11/12 | 137404 | دانلود |
