چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| ناهیده قره آغاجی | اول |
| صمد حسنی آغوزی | دوم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Nanoparticles, Photothermal therapy (PTT), Cancer, Magnetic resonance imaging (MRI) |
| خلاصه مقاله | Introduction: Nanoparticles-based image-guided therapy has shown great potential for cancer treatment in recent years. Photothermal therapy (PTT) is an emerging method that utilizes photothermal agents to absorb near-infrared (NIR) light and generate localized hyperthermia to destroy cancerous cells with minimal side effects. Magnetic resonance imaging (MRI) paves the way for effective and safe PTT via real-time imaging and monitoring of the therapeutic process. This study aimed to review the properties of the nanoparticles used in MRI-guided PTT of cancer. Methods: The keywords of nanoparticles, photothermal therapy (PTT), cancer, and magnetic resonance imaging (MRI) were entered in the scientific databases of Scopus, Google Scholar, and PubMed. Then the most relevant searched articles were reviewed. Results: Nanoparticles-assisted photothermal therapy (NPTT) under MRI guidance can be classified into three categories based on the application frequency: (i) Gold-based nanoparticles; which have a strong optical absorbance in the NIR region (700 – 1300 nm) due to their surface Plasmon resonance effects; (ii) Magnetic nanoparticles; such as iron oxide nanoparticles which possess good photothermal properties and also can be employed as MRI nanoprobes; (iii) carbon-based nanoparticles; such as graphene derivatives which have a significant ability to convert absorbed light into heat. The nanoparticles expressed in all three categories showed good biocompatibility, low toxicity to normal tissues, and highly effective cancer cell ablation in vitro and in vivo. Conclusion: Using NPTT under MRI guidance provides the basis for the multifunctional probes combining high anticancer efficacy of PTT and MRI monitoring in a single nanoplatform. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Abstract page 1.JPG | 1401/10/04 | 83352 | دانلود |
| Abstract page 2.JPG | 1401/10/04 | 81659 | دانلود |
| Certificate Nanoparticles-assisted.pdf | 1401/10/04 | 364109 | دانلود |
