چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | سیمین شریفی |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | مرکز تحقیقات لثه و دندان |
| کد مقاله | 80411 |
| عنوان فارسی مقاله | RUTIN NANOCRYSTALS AS A SUITABLE AGENT AS AN ANTIBIOTIC AND ANTICANCER AGENT TO REDUCE ECOSYSTEM POLLUTION |
| عنوان لاتین مقاله | RUTIN NANOCRYSTALS AS A SUITABLE AGENT AS AN ANTIBIOTIC AND ANTICANCER AGENT TO REDUCE ECOSYSTEM POLLUTION |
| نوع ارائه | پوستر |
| عنوان کنگره / همایش | کنفرانس بین المللی "تنوع زیستی، منابع زمین و آب شوش و مناطق اطراف: چشم اندازی از آینده" |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Azerbaijan |
| شهر محل برگزاری کنگره/ همایش | Susa |
| سال انتشار/ ارائه شمسی | 1401 |
| سال انتشار/ارائه میلادی | 2022 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1401/06/31 الی 1401/07/11 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://science.gov.az/az/news/open/20134 |
| آدرس علمی (Affiliation) نویسنده متقاضی | Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| سیمین شریفی | اول |
| سولماز ملکی دیزج | دوم |
| سپیده زنونی واحد | سوم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Rutin nanocrystals; antibiotic; anticancer |
| خلاصه مقاله | Pharmaceutical substances are excreted through feces and urine as a mixture of the main compounds and unchanged metabolites and can enter the aquatic environment through hospital effluents and wastewater treatment plants, landfill leachates, and to some extent in the pharmaceutical industry discharges. Their continuous entry into the aquatic compartment means that they are constantly present in the environment. Anticancer drugs are a group of chemotherapy agents produced to prevent or impair the proliferation of cancer cells. Many of these drugs are carcinogenic, mutagenic, teratogenic and/or cytotoxic to the reproductive system and are classified as extremely hazardous compounds. Antibiotics can challenge the population of microbes, they should also be considered important pollutants in the ecosystem. It is necessary to increase awareness about the potential of anticancer drugs and antibiotics as contaminants of emerging concern in terrestrial and aquatic ecosystems. Wastewater contamination with a wide range of microbiological, chemical, and cytotoxic material is one of the growing environmental concerns. The present study was conducted with the aim of introducing a new strategy to reduce environmental contaminations caused by antibiotics and anticancer drugs. Compared to other antimicrobial agents, nanoparticles have the least toxicity to the ecosystem. Therefore, they can be a wise choice for the preparation of anticancer and antimicrobial agents. Rutin is a herbal bioactive agent widely present in vegetables and fruits with numerous therapeutic effects, primarily related to its effective antioxidant and anti-inflammatory effects. Rutin has low aqueous solubility and poor bioavailability, which limits its therapeutic usage. The development of nanoparticle systems is one of the ways to increase the bioavailability and solubility of rutin. The present study aimed to prepare rutin nanocrystals (RNs) and examine the anticancer and antimicrobial effects. The ultrasonic method was used for the preparation of RNs. Then the prepared RNs were physicochemically characterized by conventional methods. The minimum inhibitory concentration (MIC) of RNs was investigated against several bacterial strains compared to bulk rutin. The average particle size of RNs was 75 ± 0.16 nm with quasispherical morphology. RNs were more effective than bulk rutin against the investigated bacteria. The cytotoxicity of RNs and bulk rutin on the cancer cells was assessed. cancer cells were also treated with RNs for evaluation of anticancer mechanism. The results suggest that RNs may be useful as a protocol for the treatment of cancers and infections without environmental contamination. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Susa konfrans_RUTIN NANOCRYSTALS.pdf | 1401/09/16 | 601601 | دانلود |
| Poster-Susa.pdf | 1401/09/16 | 403022 | دانلود |
| Susa konfrans-eBook.pdf | 1401/09/16 | 18537504 | دانلود |
