چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| ثمین حمیدی | اول |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Prostate cancer is the second most common cancer in men and the fourth most common cancer. Prostate cancer is an invasive disease and usually manifests itself in the advanced stage of the disease [1]. The present study aimed to analyze the characteristics of metabolic amino acids as a biomarker identification strategy for early detection and screening of prostate cancer [2]. Biological samples are given to patients in the early and often asymptomatic stages of cancer. What is necessary is the changes observed in the amino acid profiles of these patients. Among several analytical methods, the LC-ESI-MS/MS is a promising tool. In this experimental study, we are dealing with complex biological samples, so a new extraction method of magnetic dispersive solid phase extraction (MDSPE) using layered double hydroxide (LDH) is used to purify and concentrate amino acids [3]. The synthetic magnetic adsorbent and the effective factors of the extraction method are investigated and optimized one by one. This study obtains and analyzes the free amino acid profiles in the plasma of prostate cancer patients and healthy men. Given the contradictory results in changing the amino acid profile in cancers and the high prevalence of prostate cancer in Iran, and the lack of an epidemiological study on plasma amino acid levels in patients with prostate cancer, this study could provide the basis for further studies. Determination of amino acid properties using the non-invasive HPLC-Tandem MS method and the new MDSPE method help to easily separate amino acids from the complex medium and determine them rapidly. |
| کلمات کلیدی | Amino acid, Biomarker, Magnetic dispersive solid phase extarction |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Amino acid.jpg | 1401/09/14 | 1693637 | دانلود |
| ICB2022 Aminoacids.pdf | 1401/09/14 | 1347163 | دانلود |
