چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| زهرا تقی نژاد | اول |
| محمد اصغرزاده | دوم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Hematologic Neoplasms, Leukemia, MicroRNAs, Diagnosis |
| خلاصه مقاله | Abstract Introduction: Hematological malignancies (HMs) are extremely heterogeneous diseases with a rising death rate all over the world. Sensitive, early, noninvasive diagnosis and disease categorization in hematological malignancies would be highly helpful for more potent treatments. Small non-coding RNA molecules known as microRNAs(miRNAs) range in length from 19 to 22 nucleotides and are involved in the post-transcriptional regulation of genes as well as different cellular processes. As the change in the expression of miRNAs has been linked to the etiology of hematologic malignancies, they can be utilized in the diagnosis of HMs. Materials and Methods: In September 2022, search was conducted using PubMed and Google Scholar to find English pertinent research papers from 2016 to 2022. Hematologic Neoplasms, Leukemia, MicroRNAs, and Diagnosis were utilized as keywords in the title or abstract. Results:409 relevant literatures were found by searching for Hematologic Neoplasms, Leukemia, Lymphoma, MicroRNAs, and Diagnosis in English-language papers from 2015 to 2022 in PubMed and Google Scholar. 20 of the most pertinent papers were included in the study after reviewing the title and abstracts of the yielded studies. Conclusion: Acute myeloid leukemia is linked to tumor-suppressive miRNAs like miR-96 and miR-328 as well as oncogenic miRNAs like miR-210, mir-331, miR-191, and miR-199a. Downregulation of miR-223, miR-27, miR-37, miR451, and miR-342 and upregulation of miR-708, miR-128, let-7i, and miR-7 are linked with acute lymphoid leukemia(ALL). In chronic myeloid leukemia(CML), miR-23a, miR-150, and miR-320a expression levels are downregulated. Chronic lymphoid leukemia(CLL) is characterized by the overexpression of the miRNAs 25-3p, 19a-3p, 145, and 144 and the reduced expression of the miRNAs 133b, 30d, and 451a. So these results suggest that miRNA-expression profiling may play a significant role in the precise diagnosis of HMs. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 20221019_091833.jpg | 1401/08/07 | 3158610 | دانلود |
| 20221019_202304.jpg | 1401/08/07 | 3925752 | دانلود |
