چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| رسا بهشتی | اول |
| علی نوروزی | دوم |
| سما رهنمایان | سوم |
| حسین حسینی فرد | چهارم |
| مرتضی قوجازاده | پنجم |
| علیرضا لطفی | ششم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | alcohol intoxication; drunk driving; fMRI; Meta-Analysis; Systematic Review |
| خلاصه مقاله | Aim: Drunk driving is one of the main causes of traffic accidents. Years of functional magnetic resonance imaging (fMRI) research have revealed various effects of alcohol intoxication on drivers' brains, but there is no comprehensive summary of the exactly involved brain regions. Our aim was to conduct a meta-analysis to develop more effective intervention efforts for alcohol use disorder. Methods: Medline and other available databases were systematically searched to retrieve fMRI studies in the field of alcohol intoxication in drivers in comparison to non-intoxicated drivers. Articles were screened based on eligibility criteria. Meta-analysis was performed with the ALE method in GingerALE2.3.6 on MNI and Talairach coordinates from included studies. ALE maps were set at a threshold of P<0.05 and viewed with Mango software. Results: 4 articles were included in the meta-analysis. In comparison to non-inebriated drivers, ALE analysis revealed that alcohol-intoxicated drivers have significantly lower activation of the medial region of the right superior frontal gyrus, left thalamus, and left anterior cingulate gyrus. They also had higher activation in the right parietal operculum, right planum polare, right precentral gyrus, medial segment of right superior frontal gyrus, right superior frontal gyrus, left angular gyrus, left superior frontal gyrus, left superior motor cortex, and left superior frontal gyrus. Conclusion: This study is the first meta-analysis to offer key hyper- and hypo-activation regions of the brain while drunk driving. The obtained regional abnormalities in this study might serve as biomarkers to effectively understand the underlying brain mechanisms of impaired driving performance while intoxicated. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Certificate.pdf | 1401/07/30 | 134951 | دانلود |
| FENS Forum 2022 abstract.pdf | 1401/07/30 | 69383 | دانلود |
