چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| محمد رضا اردلان | چهارم |
| فرهنوش فرنود | اول |
| علیرضا مردمی | دوم |
| سپیده زنونی واحد | چهارم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | kidney transplant luminex |
| خلاصه مقاله | Introduction Renal transplantation is the main therapy for end stage renal diseases (ESRDs). Despite successful treatments by immunosuppressive drugs after allogeneic transplant, there are multiple issues in finding an appropriate donor for highly sensitized patients. The aim of this study was to evaluate the prevalence and titers of anti-HLA-class I and antiHLA-class II antibodies in highly sensitized patients. The history of the risk factors of sensitization including transplantation, blood transfusion, and pregnancy was also studied. Patients and Methods After selection of twenty highly sensitized ESRD candidates with a calculated panel-reactive antibody (CPRA) equal or higher than 50%, the serum titer of Anti-HLA-I and anti-HLA-II antibodies were measured by single antigen bead (SAB) Luminex assay and reported as mean fluorescence intensity (MFI). Final analysis were performed by SPSS software. Results History of renal transplantation was the most prevalent risk factor for sensitization. Blood transfusion and pregnancy were the other risk factors Of sensitization among selected patients. Our results showed that HLA A*24:02 in anti-HLA class I and DQA1*02:01/ DQB1*06:02 in anti-HLA class II were the most frequent antibodies. In addition, MFI levels of antibodies in anti-HLA class II was significantly higher than the MFI levels of antibodies in anti-HLA class I. Conclusions According to our findings, matching HLA alleles, particularly class II antibodies before transplant could reduce sensitization in the first renal transplant. However, it is necessary to understand the sensitization status of transplant candidates by evaluating CPRA values to perform better donor matching |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Certificate.pdf | 1401/07/17 | 90919 | دانلود |
| Poster.pdf | 1401/07/17 | 1013511 | دانلود |
