| خلاصه مقاله | Introduction
Urolithiasis in children has been getting more prevalent over recent decades. Main risk factors for renal stone formation include: dehydration, high-protein/high-salt diet, and inheritance. To prevent kidney stones formation, the stones content and its related producing factors should be considered. Children and their care givers may need to change certain behaviors including eating and drinking habits.
Discussion
Increased fluid intake is recommended to all patients with kidney stones; this can dilute urine and increase urine output (≥1.5 L/m2/day) is the single most important measure of stone prevention by disabling two major stone forming mechanisms: supersaturation that causes crystal nucleation and stasis.
Reduced salt intake to 2-3 g/d is beneficial for most children especially who are at risk for calcium, oxalate or uric acid crystal formation. Limiting dietary sodium intake decreases urinary uric acid and calcium excretion.
Avoid excessive vitamin A and D supplements that can cause hypercalcemia and hypercalciuria; nevertheless, vitamin D deficiency can cause hypercalciuria too, therefore logic administration of vitamins is crucial.
Citrate supplementation helps prevent stones in patients who have hypocitraturia. Potassium and/or Magnesium citrate are usual drug preparations for prescription.
Avoid High protein intake that increases urinary calcium excretion. All patients should receive the Recommended Dietary Allowance of protein for age to supply adequate substrate for growth and development.
Curtail any unusual excess of calcium intake, but calcium restriction is not recommended because of the risk of osteopenia and increased intestinal oxalate absorption.
Patients should receive adequate dietary potassium because potassium depletion increases calciuria, , particularly if they are taking diuretics.
Limiting or avoiding high-oxalate foods (such as: tea, carrots, beet, leafy green vegetables, spinach, rhubarb, chocolate, wheat bran, sesame, berries, nuts, soy, and dark-colored soft drinks) is recommended. Supplemental Vitamin B6, citrate, magnesium, and phosphorus may help decrease urinary oxalate level or its crystallization.
Dietary purine restriction is of limited value for prevention of uric acid stones; because most children do not consume significant quantities of purine-rich animal-protein foods, such as meats, anchovies (fish), mussels (shellfish), goose, brain, kidney, and liver. Hydration and sodium restriction decrease urinary uric acid excretion. If these measures fail or if patients have recurrent symptoms, base supplementation with citrate or bicarbonate may be indicated.
Prevention of cystin stones includes creating abundant flow of diluted urine and urinary alkalinization. Children who form cystine stones may need extra potassium citrate or potassium carbonate in the form of a pill or liquid medication.
Conclusion
More hydration and less salt intake are the most important dietary interventions for urinary stone prevention in children. Calcium and protein restriction are not recommended for pediatric patients with nephrolithiasis. |