چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| مهین آهنگر اسکوئی | اول |
| سیده زهرا صادقیان مطهر | دوم |
| آرزو آزادی | سوم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Introduction: Human papillomavirus (HPV) is one of the most important viral agents that are associated with several classes of cancers in humans. The aim of our study investigated the association of HPV with esophageal cancer in East Azerbaijan Province, Northwest of Iran. Methods: 140 paraffin-embedded specimens of esophageal tissue [70 patients with esophageal cancer as case group and those without diagnosed tumor in esophagus tissue as control (n=70)] were investigated using nested polymerase chain reaction (Nested-PCR) with primer design for the L1 region of HPV genome and then positive PCR products were sequenced to determine HPV type. Results: HPV DNA was isolated in 20 (28.57%) of the 70 paraffin-embedded tissue specimens of esophagus cancer. In contrast, all cases of the control group were reported negative for the HPV genome. Sequence analysis revealed that HPV types 16 and 18 are the most frequent types of HPV identified in this study. Conclusion: The prevalence of HPV in esophageal cancer can vary depending on geographic location and other factors. Based on our findings in this study, HPV infection may possibly contribute to an increased risk of esophageal cancer in a group of patients in Tabriz. |
| کلمات کلیدی | Human Papillomavirus (HPV), Esophageal Cancer (EC), Tabriz. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| HPV in cancer.pdf | 1401/06/20 | 311189 | دانلود |
| HPV1.jpg | 1401/06/20 | 357994 | دانلود |
| HPV2.jpg | 1401/06/20 | 333704 | دانلود |
