چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | ثمین حمیدی |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | مرکز تحقیقات ایمنی غذا و دارو |
| کد مقاله | 79469 |
| عنوان فارسی مقاله | تعیین مقدار ونکومایسین در نمونه های پلاسما با استفاده از استخراج فاز جامد مغناطیسی جفت شده به کروماتوگرافی مایع- طیف سنجی جرمی-جرمی |
| عنوان لاتین مقاله | Determination of Vancomycin in Plasma Samples Using Magnetic Solid-Phase Extraction Coupled to Liquid Chromatography-Tandem Mass Spectrometry |
| نوع ارائه | پوستر |
| عنوان کنگره / همایش | بیست و یکمین کنگره بین المللی شیمی |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | |
| شهر محل برگزاری کنگره/ همایش | تبریز |
| سال انتشار/ ارائه شمسی | |
| سال انتشار/ارائه میلادی | |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1401/05/04 الی 1401/05/06 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://icc21.azaruniv.ac.ir/Home |
| آدرس علمی (Affiliation) نویسنده متقاضی | Food and Drug Safety Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Pharmaceutical Analysis Research Center, Tabriz University of Medical Sciences, Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| منیره زمانی کلجاهی | اول |
| محبوب نعمتی | دوم |
| ثمین حمیدی | سوم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Vancomycin is an antibiotic of the glycopeptide class. This antibiotic has a broad spectrum of action against gram-positive and anaerobic bacteria. Adequate serum vancomycin concentration is between 5 and 10 mg/L. Higher levels are toxic, which mainly cause kidney toxicity and threaten the health of the body [1]. Concerns about health and the rational and controlled use of antibiotics are essential to minimizing antibiotic resistance. As a result, it is important to set up a sensitive analytical method for measuring antibiotics to monitor the patient's required dose [2]. Hence, in the present work, the magnetic solid phase extraction-liquied chromatography-tandem mass method is developed to determine vancomycin in human plasma as a quick and easy-to-use method to achieve the plasma concentrations of vancomycin. The present study was devoted to synthesizing Fe3O4/SiO2 nanocomposites via silica nanoparticles obtained from rice husk waste and then its functionalization using amines to obtain Fe3O4/ SiO2-NH2 as a new sorbent by improving selectivity in vancomycin sorption. The structure and morphology of the synthesized sorbent were characterized by X-ray diffraction, scanning electron microscopy, and Fourier transform infrared spectroscopy. Some important parameters affecting the extraction of the vancomycin were optimized. Under the optimized experimental conditions, the method provided a linear range of 5 to 250 ng/mL with the correlation coefficients (R2) of 0.995. The intra-day (n = 3) and inter-day precisions (n = 3 working days) calculated in the form of percent relative standard deviations (%RSDs) were below 5%. The proposed method was successfully practiced for the analysis of vancomycin in several human plasma samples, with recoveries in the range of 97.0–102.5% for the spiked samples. |
| کلمات کلیدی | Magnetic solid phase microextraction, Liquid Chromatography, Mass spectrometry, Vancomycin |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Abstract vanco.pdf | 1401/06/02 | 299217 | دانلود |
| Certificate vanco.jpg | 1401/06/02 | 79010 | دانلود |
