چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| فریبا قیاسی | اول |
| فریبا میرزائی باویل | دوم |
| رعنا کیهان منش | سوم |
| فرهاد علیزاده حشمت آباد | چهارم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | 3. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Background and Aim: In this study, the relationship between pro-inflammatory and anti-inflammatory cytokines, High-density lipoprotein (HDL), ATP Binding Cassette Subfamily A Member 1 (ABCA1) inflammatory proteins and homocysteine (atherosclerosis index) in induction of atherosclerosis was investigated. Methods: In this study, 59 males including 30 obese (Body mass index (BMI) of ≥ 30 kg/m2) and 29 normal-wight (BMI of 18.5-24.9 kg/m2) were joined to this study. Plasma levels of IL-1β and IL-10 (pg/ml), CRP (pg/ml), ABCA1 (ng/ml), HDL, Cholesterol, and Triglyceride (TG) (mg/dl), and homocysteine (µmol/l) was measured. Association of these biomarkers with homocysteine was determined. Results: Obese subjects had higher serum levels of IL10, IL1β, TG, and cholesterol concentrations (all p < 0.05 except IL-10 and cholesterol) and low levels of HDL, and ABCA1 (non-significant differences) in comparison to normal-weight group. Homocysteine levels were high in obese men with no significant differences between the two groups. In obese subjects, homocysteine had a significant inverse correlation with ABCA1, and HDL, and a strong and moderate positive correlation was found with TG levels, respectively. Conclusion: High level of homocysteine and its correlation with inflammation proteins and markers in obese subjects has key role in induction of atherosclerosis. |
| کلمات کلیدی | Arthrosclerosis, pro-inflammatory and anti-inflammatory cytokines |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Capture2.JPG | 1401/05/11 | 68726 | دانلود |
| Congre _certificate 2.pdf | 1401/05/11 | 2969077 | دانلود |
