چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| فریبا قیاسی | اول |
| فریبا میرزائی باویل | دوم |
| رعنا کیهان منش | سوم |
| یوسف ساجد گوگ تپه | چهارم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Background and Aim: To date, beneficial effects of voluntary exercise have been shown in improving diabetes-induced lung damage, but the main mechanism of its therapeutic effects have not yet been determined. Therefore, in this study, the effect of voluntary exercise on inflammatory cytokines, NF-ΚB, Nrf2 levels in lung tissue of type 2 diabetic rats was investigated. Methods: 28 male Wistar rats were allocated into four groups as follow; control group (C), exercise group (Exe), Diabetic group (Dia), diabetic +exercise (Dia- Exe). Type 2 diabetes was induced in the diabetic groups by high-fat diet for 4 weeks and intraperitoneal injection of streptozotocin (35 mg/kg). In exercise groups, animals exercised voluntarily for 10 weeks. At the end of intervention, the animals were killed by ketamine and xylazine injections, and their lung tissue was removed and IL-10, IL-11, NF-kB and Nrf2 protein levels were measured. Results: Data showed a reduction in lung tissue levels of IL-11, IL-10 and Nrf2 of diabetic groups compared to control group. Also findings showed an increase in NF-kB level in lung tissue of diabetic group compared to the C group. Voluntary exercise inhibited diabetic-induced changes. Conclusion: Voluntary exercise could decrease diabetic -induced pathological changes in lung tissue via the modulation of IL-10, IL-11, NF-kB and Nrf2 protein levels. |
| کلمات کلیدی | Diabetes; voluntary exercise lung damage; inflammatory cytokines, NF-kB, Nrf2 |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Capture.JPG | 1401/05/11 | 69405 | دانلود |
| congre_certificate 3.pdf | 1401/05/11 | 2969077 | دانلود |
