| Objective: The objective was to investigate whether a diet with high glycemic index (GI) is associated with Parkinson’s disease (PD) and changes that happen at levels of methylglyoxal (MGO), oligomeric α-synuclein (α-syn), and DJ-1. Materials and Methods: This reviewed study was carried out by doing search in Scholar Google, PubMed and Elsevier databases using keywords such as Parkinson’s disease, high glycemic index (GI), methylglyoxal (MGO), α-synuclein (α-syn), DJ-1. Approximately 40 articles were selected that were fully reviewed. Conclusions: High GI diets may be risk factor for developing PD by increasing a-syn oligomerization and advanced glycated end products (AGEs) formation. Intake of dietary fiber. Appear to be beneficial in reducing PD. |