چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Exosomes are small extracellular vesicles with sizes ranging from 30 to 150 nanometers, containing proteins, lipids, mRNAs, microRNAs, and double-stranded DNA derived from the cells of origin. Exosomes can be taken up by target cells, acting as a means of cell-to-cell communication. The discovery of these vesicles in body fluids and their participation in cell communication has led to major breakthroughs in diagnosis, prognosis and treatment of several conditions (e.g., cancer). However, the conventional isolation and evaluation of exosomes, and their microRNA contents, suffers from high costs, lengthy process, difficult standardization, low purity, and poor yield. In this regard, the emergence of microfluidic devices, which show increased efficiency in sieving, trapping, and immunological separation of small volumes, could provide improved detection and monitoring of exosomes involved in cancer. Microfluidic techniques hold promise for further advances in the development of diagnostic and prognostic devices. This review covers ongoing research on microfluidic devices for the detection of microRNAs and exosomes as biomarkers, and looks forward to their translation to point-of-care and clinical applications. |
| نویسنده | نفر چندم مقاله |
|---|---|
| جاوید صدری نهند | ششم |
| محمد تقی زادیه | چهارم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| microfluidics.pdf | 1401/04/11 | 3327823 | دانلود |
