| Metformin is a drug that needs improvement in its bioavailability and absorption. This can be
acheived by using different drug delivery systems, making prodrugs, and changing the drug release environment.
Drug delivery systems are used for various reasons, for example, targeted drug delivery, protecting
the drugs from destruction by enzymes, and enhancing the drug's absorption, permeability, and
bioavailability. According to the studies and surveys, the permeability, absorption, and bioavailability of
metformin can be improved in many ways, like making prodrugs and using carriers. Prodrugs and lipidbased
carriers like nanostructured lipid carriers and lipid-based polymers are the best methods that can help
the medical system to reduce the dose of metformin usage in patients and reduce the side effects. |