| Today, the importance of biocompatible nanocomposite films with suit-
able properties for potential applications in wound healing has been considered. In
present study, nanocomposite films of gelatin/aldehyde-gellan gum/Naringenin-
loaded Zein nanoparticle (GL/AG/NR@Z) were successfully produced with the solu-
tion casting method. NR@Z with different concentrations (1.5 and 3 wt%) loaded into
the GL/AG films. Then, the morphological, structural, thermal, and physical properties of
these films were investigated. The obtained findings illustrated that by addition of
NR@Z content, a denser and more porous structure with high swelling ratio (around
80%), high thermal stability, high tensile stress (54.33 ± 3.45 MPa), and high weight
loss (around 70%) was observed. Cell viability assessment of the produced films dis-
played no cytotoxicity for NIH3T3 fibroblast cells. Furthermore, since NR is a polypheno-
lic compound, the produced GL/AG/NR@Z nanocomposite films showed antioxidant
and antibacterial activity. Consequently, we demonstrated that nanocomposite films
(GL/AG/NR@Z) could be a suitable scaffold for wound healing applications. |