Development of Gelatin Thin Film Reinforced by Modified Gellan Gum and Naringenin-Loaded Zein Nanoparticle as a Wound Dressing

Development of Gelatin Thin Film Reinforced by Modified Gellan Gum and Naringenin-Loaded Zein Nanoparticle as a Wound Dressing


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دانشگاه علوم پزشکی تبریز
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نویسندگان: مرجان قربانی , مرتضی رئیسی

کلمات کلیدی: gelatin, aldehyde gellan gum, naringenin, zein nanoparticle, nanocomposite film, wound healing

نشریه: 23185 , 6 , 30 , 2022

اطلاعات کلی مقاله
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نویسنده ثبت کننده مقاله مرجان قربانی
مرحله جاری مقاله تایید نهایی
دانشکده/مرکز مربوطه مرکز تحقیقات علوم تغذیه
کد مقاله 78979
عنوان فارسی مقاله Development of Gelatin Thin Film Reinforced by Modified Gellan Gum and Naringenin-Loaded Zein Nanoparticle as a Wound Dressing
عنوان لاتین مقاله Development of Gelatin Thin Film Reinforced by Modified Gellan Gum and Naringenin-Loaded Zein Nanoparticle as a Wound Dressing
ناشر 3
آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ بلی
عنوان نشریه (خارج از لیست فوق)
نوع مقاله Original Article
نحوه ایندکس شدن مقاله ایندکس شده سطح یک – ISI - Web of Science
آدرس لینک مقاله/ همایش در شبکه اینترنت

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Today, the importance of biocompatible nanocomposite films with suit- able properties for potential applications in wound healing has been considered. In present study, nanocomposite films of gelatin/aldehyde-gellan gum/Naringenin- loaded Zein nanoparticle (GL/AG/NR@Z) were successfully produced with the solu- tion casting method. NR@Z with different concentrations (1.5 and 3 wt%) loaded into the GL/AG films. Then, the morphological, structural, thermal, and physical properties of these films were investigated. The obtained findings illustrated that by addition of NR@Z content, a denser and more porous structure with high swelling ratio (around 80%), high thermal stability, high tensile stress (54.33 ± 3.45 MPa), and high weight loss (around 70%) was observed. Cell viability assessment of the produced films dis- played no cytotoxicity for NIH3T3 fibroblast cells. Furthermore, since NR is a polypheno- lic compound, the produced GL/AG/NR@Z nanocomposite films showed antioxidant and antibacterial activity. Consequently, we demonstrated that nanocomposite films (GL/AG/NR@Z) could be a suitable scaffold for wound healing applications.

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نویسنده نفر چندم مقاله
مرجان قربانیاول
مرتضی رئیسیسوم

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