چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| رقیه مولانی | اول |
| ثریا خیروری | دوم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Quercetin, Apoptosis, Human breast cancer, MCF-7, MDA-MB-231 |
| خلاصه مقاله | Introduction: Breast cancer that occurs in the mammary gland epithelial tissue is a malignant tumor, and it is the main cause of cancer deaths in women in less developed countries and ranked the second after lung cancer in developed countries. Annually, more than 1.3 million women are diagnosed with breast cancer around the world. This systematic review was performed with a focus on the effects of quercetin (QT) on the human breast cancer cells. Method: PubMed, Scopus, and Science Direct databases and Google Scholar were searched using the following keywords: “quercetin” or “polyphenol” or “flavonoid” or “phytoestrogen” and “breast cancer” or “apoptosis and breast cancer”. The search was limited until May 2020. All articles written in English evaluating the effects of QT on the human breast cancer cell lines MCF-7 and/or MDA-MB-231 were eligible for the review. Results: Finally, 31 articles were included in this systematic review. Reviewed studies showed that in cancerous cells, QT caused apoptosis via oxidative stress and mitochondrial dysfunction, up-regulation of the pro-apoptotic protein, down-regulation of anti-apoptotic protein, and cell cycle regulatory proteins. Also, QT possibly directly induces apoptosis through DNA fragmentation and morphological alterations of breast cancer cells. Conclusion: It is concluded that QT causes apoptosis in human breast cancer cell lines MCF-7 and MDA-MB-231 and might be beneficial in the eliminating of breast cancer cells. However, further clinical trials are warranted to further verify these outcomes. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Govahi.pdf | 1401/03/23 | 174885 | دانلود |
| HN-01980086.pdf | 1401/03/23 | 72146 | دانلود |
