چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Aims of the Study. Reducing estrogen levels due to menopause activates oxidative and inflammatory processes, which causes symptoms of menopause, anxiety, and sexual dysfunction. As a suggestion, potential anti-inflammatory and antioxidant agents such as curcumin and vitamin E could be used as an eactive alternative treatment due to parsimony, suitable access, and fewer side effects. Therefore, the present study was conducted to nd out whether supplementation with curcumin and vitamin E affects inflammatory oxidative stress biomarkers and primary symptoms of menopause in healthy postmenopausal women. Methods Used to Conduct the Study. The present study is a triple-blind parallel randomized controlled trial. Eighty-four eligible postmenopausal women aged 40 to 60 years old were randomly assigned into three groups using block randomization with an allocation ratio of 1 :1 :1. e curcumin group received one capsule containing 500 mg curcumin twice a day, the vitamin E group received one 500 mg capsule of vitamin E twice a day, and the placebo group took two placebo capsules containing 500 mg of microcrystalline cellulose (MCC) daily for eight weeks. Demographic and anthropometric characteristics, dietary intake, and early symptoms of menopause were collected at baseline. Serum levels of total antioxidant capacity (TAC), malondialdehyde (MDA), and high sensitivity C-reactive protein (hsCRP) were measured at baseline and after the intervention. Intervention safety and satisfaction with the intervention were also evaluated. Results of the Study. Eighty-one participants completed the trial and were finally analyzed. ere were no statistically significant differences in demographic characteristics and dietary intake of participants (except for vitamin C intake, P 0.023) between the groups at baseline. e mean ± standard deviation (SD) score of total menopause symptoms, depression, anxiety, psychological, vasomotor, and physical domains significantly decreased within all groups (P < 0.05). Between-group analyses indicated that decreasing the mean score of anxiety in the vitamin E group was significantly more than in the placebo group (P 0.026). e mean (SD) serum levels of MDA and hs-CRP significantly decreased only in the curcumin group (P 0.009 and P 0.025, respectively). Serum levels of TAC significantly increased in curcumin and vitamin E groups (P < 0.001 and P 0.006, respectively). Conclusions Drawn from the Study and Clinical Implications. Curcumin could improve the oxidative stress (MDA and TAC) and inflammatory (hs-CRP) biomarkers. Vitamin E may also improve the antioxidant status by increasing the TAC levels. e alleviation of anxiety in the vitamin E group was more than in the placebo group. Clinical Trial Registration. e trial was registered at the Iranian Registry of Clinical Trials (https://irct.ir/IRCT20131009014957N6) |
| نویسنده | نفر چندم مقاله |
|---|---|
| عزیزه فرشباف خلیلی | اول |
| علیرضا استاد رحیمی | دوم |
| مژگان میرغفوروند | سوم |
| خاطره عطائی آلمانقدیم | چهارم |
| سارا دوستی | پنجم |
| امیرمهدی ایرانشاهی | ششم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 137 curcumin Vitamin E.pdf | 1401/03/22 | 642746 | دانلود |
