چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| The solubility study of drugs in aqueous and organic solvents has practical importance in pharmaceutical industries. In this research work, the solubilities of satranidazole (SAT) were determined in 18 monosolvents, namely, methanol (MeOH), ethanol (EtOH), 1-propanol (1-PrOH), 2-propanol (2-PrOH), formamide, 1,4-dioxane, N,N-dimethyl formamide (DMF), N,N-dimethyl acetamide (DMA), dimethyl sulfoxide (DMSO), N-methyl-2-pyrrolidone (NMP), ethylene glycol (EG), propylene glycol (PG), 1,4-butanediol (BDOH), glycerin, polyethylene glycol-200 (PEG-200), PEG-400, PEG-600, and water, at five different temperatures (T = 293.2–313.2 K) and atmospheric pressure (p = 0.1 MPa). Experimental solubilities expressed in the molar fraction of SAT were correlated well with thermodynamic models including van’t Hoff model, Apelblat model, Buchowski–Ksiazczak model, and polynomial empirical model. The molar fraction solubility of SAT was recorded highest in NMP (7.963 × 10–2 at T = 293.2 K) followed by DMSO, formamide, DMF, DMA, PEG-600, PEG-400, PEG-200, 1,4-dioxane, PG, EG, BDOH, glycerin, MeOH, EtOH, 1-PrOH, 2-PrOH, and water as expected over the entire temperature range investigated. |
| نویسنده | نفر چندم مقاله |
|---|---|
| ابوالقاسم جویبان | سوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| ss66.pdf | 1401/02/31 | 1399796 | دانلود |
