چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Abstract Background: It is suggested that selenium has a protective role against oxidative stress and intraoperative decrease of its levels might be a predictive factor for postoperative multi organ failure. We investigated the effects of administration of high doses of selenium in cardiac surgery with CPB patients. Methods: This randomized double-blind clinical trial took place in the department of cardiac surgery of an academic hospital affiliated with Tabriz University of Medical Sciences, 144 elected cardiac surgery patients(selenium group (S) n=72, and placebo group (P) n=72 ) with CPB were allocated to the two control or selenium groups (from 2016 to 2017). They received either an intravenous bolus of 4000 µg selenium after induction of anesthesia, 1,000 μg/day on the following days in Intensive Care Unit or normal saline as a placebo. Cardiopulmonary pump time, use of inotropic drugs and type and dose of vasopressors during in surgery and Intensive Care Unit, mechanical ventilation time, post-operative complication, Sequential Organ Failure Assessment Score, Intensive Care Unit stay time were recorded. Result: There was no significant difference between the two groups with regard the primary cause of surgery and also preoperative Laboratory tests including. In Patients received selenium, Intensive Care Unit staying after operation (P=0.009) Mechanical ventilation time (P=0.035) and Total staying in hospital (P=0.001) and Sequential Organ Failure Assessment score were lower than the other group. Conclusion: In this study, intravenous selenium 4000μg loading dose followed by 1000μg ordinary for 7 days in patients undergoing cardiac surgery using a cardiopulmonary pump significantly reduces the duration of mechanical ventilation as well as the length of hospital stay Specially the incidence of organ failure and Sequential Organ Failure Assessment score. |
| نویسنده | نفر چندم مقاله |
|---|---|
| عیسی بیله جانی | اول |
| بهمن نقی پور باسمنج | دوم |
| سولماز فخاری | سوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| LEAD112976-1.pdf | 1401/02/28 | 329129 | دانلود |
| ali.pdf | 1403/07/08 | 103988 | دانلود |
| Ali2.pdf | 1403/07/08 | 141012 | دانلود |
