چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Introduction Phlomoides species have long been used in ethnomedicine for various purposes, such as stomach disorders and wound healing. The aim of this study was to investigate some phytochemical and biological features of one species, Phlomoides labiosa. Methods The aerial part, rhizome, and the seed of P. labiosa were extracted using various solvents with increasing polarity. Essential oil and fatty acid contents were analyzed via GC/MS method. Antioxidant, antibacterial, and cytotoxic properties were evaluated in all samples. After that, extract nanoliposomes were created to improve the biological effects by increasing the solubility. Results Obtained results indicated that oleic acid is assumed as the major component of seed oil with a total fatty acid content of 37.62 (w/w %). Ethyl acetate and methanol extracts indicated the antioxidant activity was in line with the phenol contents. The most potent antibacterial effects were associated with the ethyl acetate extracts of aerial part and seed. The dichloromethane extract of the aerial part showed the highest cytotoxicity among all tested samples (IC50=40.88±16.05 µg/mL). Despite the hypothesis of the encapsulated extracts having better effects, nanoparticles indicated lower biological activities than free forms. Conclusions Because of the high amount of oleic acid and overall yield, the seed oil may be suitable for nutritional reasons. The antibacterial activity of ethyl acetate extract and the considerable cytotoxicity of dichloromethane extract make them potential candidates for future assessments. Limited extract release from the membranes of nanoliposomes may be the main reason for biological activity reduction. |
| نویسنده | نفر چندم مقاله |
|---|---|
| ثمین محمدی | اول |
| هادی ولیزاده | دوم |
| فرناز خالصه | سوم |
| سپیده باستانی | چهارم |
| عباس دل آذر | پنجم |
| پرینا اصغریان | ششم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Article.pdf | 1401/02/20 | 2093210 | دانلود |
