چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Eelectrospun fibrous mats for oral ulcer dressing should be able to attach oral mucosa in a high moisture environment and provide desirable therapeutic effects. Ethylcellulose and Gliadin are appropriate polymers in this regard. In the current study, first, Triamcinolone was integrated into Gliadin/Ethylcellulose fibrous mats (Triamcinolone/Gliadin/Ethylcellulose). Then, the chemical structure, thermal stability, mechanical properties, and morphology of Triamcinolone/Gliadin/Ethylcellulose fibrous mats were evaluated by Fourier Transform Infrared Spectroscopy, thermal gravimetric analysis (TGA), Tensile stress analysis, and scanning electron microscopy, respectively. Moreover, the biocompatibility, anti-inflammatory, and antioxida- tive effects of these fibrous mats were evaluated on human gingival fibroblasts. The results of SEM confirmed the uniform structure of the fabricated fibrous mats. The mechanical strength and the thermal stability of fibrous mats containing Triam- cinolone were improved compared with Gliadin/Ethylcellulose fibrous mats. In vitro analysis showed the non-cytotoxicity of these fibrous mats on HGFs. Moreover, expression levels of TNF α and IL 6 in fabricated mats were 0.995 pg/mL and 0.44 pg/mL, which were significantly less than the control group. Also, the measurement of ROS activity showed significant decreases in stimulated HGFs. According to these results, it seems that the Triamcinolone/Gliadin/Ethylcellulose would be a practical mat for application in the treatment of oral inflammatory ulcers |
| نویسنده | نفر چندم مقاله |
|---|---|
| مهدیه علیپور | اول |
| مرضیه آقازاده | دوم |
| ثنا طاهرزاده | چهارم |
| مرجان قربانی | پنجم |
| زهرا آقازاده | ششم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Ghorbani,2022,107.pdf | 1401/02/17 | 4056206 | دانلود |
