چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | مهدیه راوی معروفی |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | دانشکده داروسازی |
| کد مقاله | 78600 |
| عنوان فارسی مقاله | ارزیابی اثرات سلکوکسیب و کروسین در پیشگیری از بروز وابستگی در موش سوری |
| عنوان لاتین مقاله | Evaluation of the effects of celecoxib and crocin in the prevention of Morphine induced dependence in mice |
| نوع ارائه | سخنرانی |
| عنوان کنگره / همایش | 3rd International Congress on Pharmacy Updates |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | تهران |
| سال انتشار/ ارائه شمسی | 1398 |
| سال انتشار/ارائه میلادی | 2020 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1398/11/16 الی 1398/11/18 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://www.pharmacyupdates.com/media/attachments/1399/02/02/finalized-abstracts.pdf |
| آدرس علمی (Affiliation) نویسنده متقاضی | Department of Pharmacology, School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| بهلول حبیبی اصل | اول |
| طاهره اعتراف اسکوئی | دوم |
| سارا مجیدپور | سوم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | dependency, morphine, crocin, celecoxib, mice |
| خلاصه مقاله | Introduction: Inflammatory factors and Oxidative stress affect the opioid system. Celecoxib, is an anti- inflammatory drug and crocin (saffron extract) as an herbal agent have antioxidant activity. The aim of the present study was to investigate the effects of celecoxib and crocin in the prevention of Morphine induced dependence in mice. Materials and Methods: Ten groups containing 9 male mice in weight group 20-30 gr were randomly selected and received the regimens mentioned below once daily for 4 days. 1) Saline (10 ml/kg, ip) + Saline (10 ml/kg, ip) 2) Morphine (50 mg/kg, ip) + Saline (10 ml/kg, ip) 3) Morphine (50 mg/kg, ip) + tween80(5%w/v,10ml/kg, ip) 4,5,6) Morphine (50 mg/kg, ip) + crocin (100,200,400 mg/kg, ip) 7,8,9) Morphine (50 mg/kg, ip) + celecoxib (5,10,20 mg/kg, ip) 10) Morphine (50 mg/kg, ip) + crocin (100 mg/kg, ip) + celecoxib (5 mg/kg, ip) To investigate the effect of drugs on Morphine dependency on day 4th ,2 hours after the last dose of Morphine injection, Naloxone was injected and symptoms of withdrawal syndrome (number of jumping and standing on feet) were recorded within half an hour in each mice. Eventually to evaluate the effect of these drugs on pro-inflammatory cytokines, blood samples from the heart of the animals were taken and tests for TNF-α were performed. Results: The results showed that administration of celecoxib and crocin (100,200 mg/kg) before daily injection of Morphine, didn’t decrease Morphine dependency. Significant difference was not observed between (celecoxib or crocin) and morphine dependent groups |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Govahi Sara Majidpour.pdf | 1401/02/10 | 401616 | دانلود |
| finalized-abstracts.pdf | 1401/02/10 | 2470805 | دانلود |
