Mesenchymal stem cells and natural killer cells interaction mechanisms and potential clinical applications
Mesenchymal stem cells and natural killer cells interaction mechanisms and potential clinical applications
نویسندگان: بتول عباسی , کریم شمس اسنجان , مجید احمدی , سیده آمنه بهشتی کلوانق
کلمات کلیدی: Natural killer cell, Mesenchymal stem cells, Immunomodulation, Signaling, Therapeutic
نشریه: 32286 , 97 , 13 , 2022
| نویسنده ثبت کننده مقاله |
کریم شمس اسنجان |
| مرحله جاری مقاله |
تایید نهایی |
| دانشکده/مرکز مربوطه |
مرکز تحقیقات هماتولوژی و انکولوژی |
| کد مقاله |
78586 |
| عنوان فارسی مقاله |
Mesenchymal stem cells and natural killer cells interaction mechanisms and potential clinical applications |
| عنوان لاتین مقاله |
Mesenchymal stem cells and natural killer cells interaction mechanisms and potential clinical applications |
| ناشر |
5 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ |
بلی |
| عنوان نشریه (خارج از لیست فوق) |
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| نوع مقاله |
Review Article |
| نحوه ایندکس شدن مقاله |
ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت |
|
| Natural killer cells (NK cells) are innate immune cells that are activated to fght tumor cells and virus-infected cells. NK
cells also play an important role in the graft versus leukemia response. However, they can over-develop infammatory
reactions by secreting infammatory cytokines and increasing Th1 diferentiation, eventually leading to tissue damage.
Today, researchers have attributed some autoimmune diseases and GVHD to NK cells. On the other hand, it has been
shown that mesenchymal stem cells (MSCs) can modulate the activity of NK cells, while some researchers have shown
that NK cells can cause MSCs to lysis. Therefore, we considered it is necessary to investigate the efect of these two
cells and their signaling pathway in contact with each other, also their clinical applications. |
| نام فایل |
تاریخ درج فایل |
اندازه فایل |
دانلود |
| s13287-022-02777-4.pdf | 1401/02/07 | 1507346 | دانلود |