| Background: Since the outbreak of COVID-19, various treatments have been frequently
reported for patients infected with this virus, especially in transplant patients/recipients.
Objective: Investigating of kidney transplant patients under immunosuppressive therapy
infected with COVID-19 can pave the way to understanding, handling, and treatment of
COVID-19.
Methods: We had a brief review of the literature on immunosuppressive therapy in kidney
transplants infected with COVID-19. This was based on the PubMed Database with
keywords “kidney, transplant, COVID-19, and immunosuppress” after hospitalization of
kidney transplantation infected with COVID-19. He had already been recorded in the Organ
Transplant Registry (ID≠ 64510) of Tabriz University of Medical Sciences /Iran.
Results: We reported the clinical course of a 45-year-old man with a history of kidney
transplantation and immunotherapy who was infected with COVID-19 with respiratory
infections and positive RT-PCR (Real-time polymerase chain reaction). He was treated with
hydroxychloroquine, Kaletra, CellCept, and prednisolone for 5 days, and finally discharged
from the hospital. In addition, reviewing of 47 papers with 851 samples showed that
immunosuppressant medications alone could be a therapeutic choice in kidney transplants
infected with COVID-19 with careful management.
Conclusion: Patients with organ transplantation infected with COVID-19 may show
different clinical signs, clinical course, and prognosis due to underlying diseases and the use
of immunosuppressant medications. It might be best to continue taking the
immunosuppressant medications but modify them based on the patients' conditions such as
clinical symptoms, laboratory results, paraclinical examinations. |