چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Dendritic cells (DCs) can present tumoral antigens to T-cells and stimulate T-cell-mediated anti-tumoral immune responses. In addition to uptaking, processing, and presenting tumoral antigens to T-cells, co-stimulatory signals have to be established between DCs with T-cells to develop anti-tumoral immune responses. However, most of the tumor-infiltrated immune cells are immunosuppressive in the tumor microenvironment (TME), paving the way for immune evasion of tumor cells. This immunosuppressive TME has also been implicated in suppressing the DC-mediated anti-tumoral immune responses, as well. Various factors, i.e., immunoregulatory cells, metabolic factors, tumor-derived immunosuppressive factors, and inhibitory immune checkpoint molecules, have been implicated in developing the immunosuppressive TME. Herein, we aimed to review the biology of DCs in developing T-cell-mediated anti-tumoral immune responses, the significance of immunoregulatory cells in the TME, metabolic barriers contributing to DCs dysfunction in the TME, tumorderived immunosuppressive factors, and inhibitory immune checkpoint molecules in DC-based cell therapy outcomes. Withtherapy. Indeed, the combination of DC-based cell therapy with monoclonal antibodies against novel immune checkpoint molecules can be a promising strategy to increase the response rate of patients with cancers. reviewing the ongoing clinical trials, we also proposed a novel therapeutic strategy to increase the efficacy of DC-based cell |
| نویسنده | نفر چندم مقاله |
|---|---|
| فرید قربانی نژاد | اول |
| زهرا اسدزاده | دوم |
| جواد معصومی | سوم |
| امیر علی مختارزاده | چهارم |
| توحید کاظمی | پنجم |
| لیلی عاقبتی | ششم |
| سیامک صندوقچیان | هفتم |
| مهدی عبدلی شادباد | هشتم |
| امیر باغبانزاده | نهم |
| نیما همت | دهم |
| محمد بخشی وند | یازدهم |
| بهزاد برادران | دوازدهم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 602-Dendritic cell based cancer immunotherapy in the era.pdf | 1401/02/06 | 5956545 | دانلود |
