چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| In this study, a novel targeted drug delivery system was prepared based on a triazine dendrimer attached to the surface of Fe3O4@SiO2, which was then grafted with ultrahigh fluorescence folic acid-derived CDs (Fe3O4@SiO2–G2.5–CD) for targeted delivery of doxorubicin (DOX) against A549 human lung cancer cells. The successful synthesis of this system was confirmed by various techniques such as zeta potential, SEM, XRD, FT-IR, UV-visible, VSM, EDX, BET, and PL analysis. The encapsulation efficiency of Fe3O4@SiO2–G2.5–CD was 84.28% and the in vitro drug release of Fe3O4@SiO2–G2.5–CD–DOX was noticeably pH-dependent. The MTT and DAPI tests clearly exhibited that non-toxic Fe3O4@SiO2–G2.5–CD has excellent biocompatibility with A549 cells. Meanwhile, colloidal stability and enzymatic degradation studies showed that Fe3O4@SiO2–G2.5–CD has good stability and biodegradability. According to the obtained results, the as-prepared dendrimer can be proposed for use as a new safe and efficient vehicle for drug delivery systems. |
| نویسنده | نفر چندم مقاله |
|---|---|
| دکتر حسن نمازی | دوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 15 P 2021Karimi ( ROYAL SOCIERTY ).pdf | 1401/01/16 | 4264767 | دانلود |
