چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| الناز خانی | اول |
| طاهر انتظاری ملکی | دوم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Introduction: Hypertension (HTN) is a common disease that affects approximately 1 billion individuals worldwide and causes 7.1 million deaths annually. Considering the crucial role of blood viscosity (BV) in the regulation of blood pressure (BP) and hemorheological effects of pentoxifylline (PTX), we assessed the PTX role in patients with stage 1 hypertension. Material and methods: In this randomized clinical trial, 62 patients with stage 1 hypertension were entered. The intervention group (n=30) received 1200 mg PTX in three divided doses plus 25 mg captopril three times a day whereas, the control group (n=32) received only 75 mg captopril in three divided doses. Measurements of BP were done at baseline, first and second month after entering the study. Results: Comparison of the systolic BP in the intervention and the control groups showed no significant differences at baseline (150.4±6.03 vs.150.4±6.2, p=0.98), first (138.4 ±9.4 vs. 142.3 ±5.6, p=0.08) and second (134.6 ±8.9 vs. 137.4±6.0, P=0.20) months. Also, no significant difference was observed in the diastolic BP at baseline (91.7±3.9 vs. 92.0 ±3.7, p=0.84), first (85.5±5.1 vs. 86.9 ±3.8, p=0.27) and second (82.6 ±5.7 vs. 84.0 ±3.5, p=0.31) months. Discussion: Previously, several studies evaluated PTX on vascular disease and inflammation; for example, in 59 patients with type 2 diabetes and nephropathy, the effects of adding PTX to losartan on urine and serum parameters were evaluated during three months. It has been shown that in the losartan group, blood pressure was decreased more than in the PTX group. Of note, patients were normotensive in this research. (BP less than 140/90). Another study assessed the protective effects of PTX on retinopathy in 56 children with type 1 diabetes during six months, and it indicated that PTX did not have a significant effect on BP. The study population in this research had normal blood pressure. In a study by Plotnikov et al., it has been shown that in spontaneously hypertensive rats at the early stages of HTN, adding PTX to captopril could significantly improve the antihypertensive activity of captopril due to PTX effects in reducing BV. Our study has several strong points in evaluating the effect of PTX on HTN; first, unlike previous studies, it assessed the efficacy of PTX on the early stage of HTN (between 140/90 to 159/99). Second, patients in this study received just one type of anti-hypertensive agent so that analyzing the effect of PTX on BP became more reliable. Third, patients with secondary HTN did not enter this study. Fourth, this study directly evaluated the PTX effect on HTN after one and two months. Lastly, in the current study, all blood pressure measurements were according to AHA guidelines; however, the previous studies didn’t mention the blood pressure measurement method. The results of the present study were in accordance with previous research; however, more studies are required. Conclusions: According to the results of our study, adding PTX to captopril was not associated with BP reduction in patients with stage 1 hypertension |
| کلمات کلیدی | Hypertension; Pentoxifylline; Captopril |
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