چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Objective: Present research was performed to assess the effects of nanocurcumin supplementation on T-helper 17 (Th17) cells inflammatory response in patients with Behcet’s disease (BD). Methods: In this randomized double-blind, placebo-controlled trial, 36 BD subjects were randomly placed into two groups to take 80mg/day nanocurcumin or placebo for eight weeks. Disease activity, frequency of Th17 cells and expression of related parameters including retinoic acid-related orphan receptor c (RORct) transcription factor messenger RNA (mRNA), related microRNAs (miRNAs) such as miRNA-155, miRNA-181, and miRNA-326 as well as proinflammatory cytokines including interleukin (IL)-17 and IL-23 were evaluated. Results: Thirty-two patients (17 in the nanocurcumin and 15 in the placebo groups) completed the trial. Number of Th17 cells decreased significantly in the nanocurcumin group compared to baseline (p¼.012) and placebo (p¼.047). Moreover, RORct, IL-17, IL-23, miRNA-155, miRNA-181, and miRNA- 326 mRNA expression decreased significantly in the nanocurcumin group compared with baseline (p¼.004, p¼.009, p<.001, p<.001, p<.001, p<.001, respectively) and placebo (p¼.002, p¼.021, p¼.006, p¼.035, p<.001, p¼.017, respectively). Significant reductions in IL-17 and IL-23 were seen in nanocurcumin group compared with baseline (p¼.017 and p¼.015) and placebo (p¼.047 and p¼.048, respectively). Significant reduction in disease activity was observed in nanocurcumin group compared with placebo group (p¼.035). Conclusion: Nanocurcumin supplementation had favorable effects in improving inflammatory factors and disease activity in BD patients. Additional studies are warranted to suggest nanocurcumin as a safe complementary therapy in BD. |
| نویسنده | نفر چندم مقاله |
|---|---|
| روژین فرزانه | اول |
| علیرضا خبازی اسکویی | دوم |
| محمدصادق سلطانی زنگبار | سوم |
| ثمانه عباسیان | چهارم |
| آیدا مالک مهدوی | پنجم |
| رزا متولی خیاوی | ششم |
| مهدی یوسفی | هفتم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 1.pdf | 1400/12/27 | 2422356 | دانلود |
